THOC3 and DDX39B

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology)

		THOC3	DDX39B
Description		THO complex 3	DExD-box helicase 39B
Image		No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleoplasm Nuclear Speck	Transcription Export Complex Nucleus Nucleoplasm Spliceosomal Complex U4 SnRNP U6 SnRNP Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	RNA Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity ATPase Activity U6 SnRNA Binding U4 SnRNA Binding Identical Protein Binding ATP-dependent Protein Binding Protein-containing Complex Binding
	Biological Process	RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Viral MRNA Export From Host Cell Nucleus	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Liver Development RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing RNA Secondary Structure Unwinding MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Translation Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of DNA Biosynthetic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs			Artenimol
Diseases
GWAS		Chronotype ( 30696823)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean platelet volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myositis ( 26291516) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: BRCA1 DDX39B MLKL PTEN TK1	31 interacting genes: ALYREF BARD1 CHTOP DDX39A DNM2 EXOSC9 FANCA HIPK2 HNRNPLL IL7R LUZP4 NCBP2 PIAS2 RBM39 RNF4 RPS15A SARNP SDCBP SNRPA SREK1 SRPK2 STRN4 SUMO2 TDG THOC3 THOC6 TUBB3 U2AF2 UBE2I YWHAG ZHX1
Entrez ID		84321	7919
HPRD ID		09497	00805
Ensembl ID		ENSG00000051596	ENSG00000198563
Uniprot IDs		Q96J01	A0A024RCM3 Q13838
PDB IDs			1T5I 1T6N 1XTI 1XTJ 1XTK
Enriched GO Terms of Interacting Partners?
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