DDX39B and NCBP2

Data Source:
BioGRID (pull down)

		DDX39B	NCBP2
Description		DExD-box helicase 39B	nuclear cap binding protein subunit 2
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GO Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Spliceosomal Complex U4 SnRNP U6 SnRNP Cytoplasm Nuclear Matrix Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol MRNA Cap Binding Complex Nuclear Cap Binding Complex RNA Cap Binding Complex
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity ATPase Activity U6 SnRNA Binding U4 SnRNA Binding Identical Protein Binding ATP-dependent Protein Binding Protein-containing Complex Binding	RNA Cap Binding RNA 7-methylguanosine Cap Binding RNA Binding MRNA Binding Protein Binding SnRNA Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Liver Development RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing RNA Secondary Structure Unwinding MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Translation Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of DNA Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription 7-methylguanosine MRNA Capping RNA Export From Nucleus MRNA Export From Nucleus SnRNA Export From Nucleus Regulation Of Translational Initiation Histone MRNA Metabolic Process RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Gene Silencing By RNA MRNA 3'-end Processing Positive Regulation Of MRNA 3'-end Processing SnRNA Transcription By RNA Polymerase II MRNA Cis Splicing, Via Spliceosome Positive Regulation Of RNA Export From Nucleus Nuclear Export Pre-mRNA Cleavage Required For Polyadenylation Regulation Of MRNA Polyadenylation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	SLBP independent Processing of Histone Pre-mRNAs Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Abortive elongation of HIV-1 transcript in the absence of Tat snRNP Assembly RNA Polymerase II Pre-transcription Events FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs Processing of Intronless Pre-mRNAs Signaling by FGFR2 IIIa TM Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Artenimol
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean platelet volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myositis ( 26291516) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)	Malaria ( 31844061) Night sleep phenotypes ( 27126917) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		31 interacting genes: ALYREF BARD1 CHTOP DDX39A DNM2 EXOSC9 FANCA HIPK2 HNRNPLL IL7R LUZP4 NCBP2 PIAS2 RBM39 RNF4 RPS15A SARNP SDCBP SNRPA SREK1 SRPK2 STRN4 SUMO2 TDG THOC3 THOC6 TUBB3 U2AF2 UBE2I YWHAG ZHX1	7 interacting genes: DDX39B EIF4G1 EIF5 HNRNPF HNRNPH1 LZTS2 NCBP1
Entrez ID		7919	22916
HPRD ID		00805	05503
Ensembl ID		ENSG00000198563	ENSG00000114503
Uniprot IDs		A0A024RCM3 Q13838	B3KSB0 P52298
PDB IDs		1T5I 1T6N 1XTI 1XTJ 1XTK	1H2T 1H2U 1H2V 1H6K 1N52 1N54 3FEX 3FEY 5OO6 5OOB 6D0Y
Enriched GO Terms of Interacting Partners?
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