TCHP and KRT18

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		TCHP	KRT18
Description		trichoplein keratin filament binding	keratin 18
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Desmosome Keratin Filament Apical Cortex	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction External Side Of Plasma Membrane Protein-containing Complex Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Apoptotic Process Cell Projection Organization Negative Regulation Of Cell Growth Negative Regulation Of Cilium Assembly	Cell Cycle Anatomical Structure Morphogenesis Response To Fructose Viral Process Keratinization Response To Nutrient Levels Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Hepatocyte Differentiation Mesenchymal Stem Cell Differentiation Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion Cholangiocyte Apoptotic Process
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolite levels (MHPG) ( 23319000) Myocardial infarction ( 30226566) Platelet count ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		52 interacting genes: ATPAF2 BCAS2 C21orf91 CBY2 CCDC125 CCDC13 CCDC172 CCDC85B CDR2 CDR2L DMAP1 DYDC1 EIF4ENIF1 HOOK2 ID2 IFFO1 IKZF3 KCTD17 KIAA0753 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT32 KRT34 KRT35 KRT40 KRT5 KRT6A KRT75 KRT8 MIIP MIPOL1 MKRN3 MTUS2 NAB2 NDOR1 NME7 NUP54 PRDM16 PSMB5 RABGEF1 RUSC1 TEX11 TRIM27 TRIM54 USHBP1 VIM WWOX ZIM2	91 interacting genes: BBS1 BBS2 BBS4 BBS7 C1orf109 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCHCR1 CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EFHC1 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KIFC3 KPNA2 KRT15 KRT5 KRT6A KRT6C KRT71 KRT72 KRT79 KRT8 KRT81 LDOC1 LINC01554 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RCOR3 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TEKT4 TNFRSF1B TRADD TSG101 TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		84260	3875
HPRD ID		14403	01020
Ensembl ID		ENSG00000139437	ENSG00000111057
Uniprot IDs		A0A024RBM9 Q9BT92	A0A024RAY2 P05783
PDB IDs
Enriched GO Terms of Interacting Partners?
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