TCHP and RABGEF1

Data Source:
BioGRID (two hybrid)

		TCHP	RABGEF1
Description		trichoplein keratin filament binding	RAB guanine nucleotide exchange factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Centrosome Cytosol Plasma Membrane Desmosome Keratin Filament Apical Cortex	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	Protein Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Apoptotic Process Cell Projection Organization Negative Regulation Of Cell Growth Negative Regulation Of Cilium Assembly	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity
Pathways			TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolite levels (MHPG) ( 23319000) Myocardial infarction ( 30226566) Platelet count ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)
Interacting Genes		52 interacting genes: ATPAF2 BCAS2 C21orf91 CBY2 CCDC125 CCDC13 CCDC172 CCDC85B CDR2 CDR2L DMAP1 DYDC1 EIF4ENIF1 HOOK2 ID2 IFFO1 IKZF3 KCTD17 KIAA0753 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT32 KRT34 KRT35 KRT40 KRT5 KRT6A KRT75 KRT8 MIIP MIPOL1 MKRN3 MTUS2 NAB2 NDOR1 NME7 NUP54 PRDM16 PSMB5 RABGEF1 RUSC1 TEX11 TRIM27 TRIM54 USHBP1 VIM WWOX ZIM2	50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C
Entrez ID		84260	27342
HPRD ID		14403	11477
Ensembl ID		ENSG00000139437	ENSG00000154710
Uniprot IDs		A0A024RBM9 Q9BT92	A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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