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PIP4K2B and CLK1
Data Source:
BioGRID
(enzymatic study)
PIP4K2B
CLK1
Description
phosphatidylinositol-5-phosphate 4-kinase type 2 beta
CDC like kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Autophagosome
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Nucleus
Cytoplasm
Molecular Function
Protein Binding
ATP Binding
GTP Binding
1-phosphatidylinositol-4-phosphate 5-kinase Activity
1-phosphatidylinositol-5-phosphate 4-kinase Activity
Protein Homodimerization Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Biological Process
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Cell Surface Receptor Signaling Pathway
Regulation Of Autophagy
Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Insulin Receptor Signaling Pathway
Phosphatidylinositol Phosphorylation
Autophagosome-lysosome Fusion
Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process
Positive Regulation Of Autophagosome Assembly
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Regulation Of RNA Splicing
Protein Autophosphorylation
Pathways
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus
Drugs
Fostamatinib
Debromohymenialdisine
CHGN111
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Fostamatinib
Diseases
GWAS
Height (
28552196
20881960
31562340
)
Breast cancer (
27117709
)
Breast cancer (estrogen-receptor negative) (
27117709
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
17 interacting genes:
BTK
CDCA7L
CLK1
CSNK2A1
HMBOX1
HSPB7
INO80B
KYNU
MLH1
PRPF3
PSMB1
RPRD1B
TNFRSF1A
TRIM55
TRIM63
UBQLN4
ZNF131
166 interacting genes:
ABCA13
ACOX2
ANKFY1
ARHGEF12
ARPC4
ASL
ASXL3
ATP10A
ATP4A
BCLAF1
C1orf94
CDCP1
CDH23
CDK12
CELSR3
CENPE
CEP95
CFAP20DC
CFAP251
CKAP5
CLASRP
CLK2
COCH
CRNKL1
CTNND2
CUL3
CWC27
CYP46A1
DBR1
DENND4A
DNAJC13
DNAJC24
DOCK9
DPYD
DSC2
DVL3
ECE1
ELP6
ENO1
ERFE
FAM189A1
FAT1
FBF1
FHIP2B
GEMIN5
GOLM1
GRM6
GSDMB
H2BC12
HADH
HIVEP1
HNMT
HNRNPA0
HNRNPA1
HNRNPA3
HSP90AB2P
HSPBP1
HTATSF1
ICE1
IMPDH2
IP6K1
ITGA5
KATNA1
KHDRBS1
KIF14
KIF23
KRT8
KRTAP10-6
KRTAP10-7
LINS1
LMNA
LNX1
LUC7L3
MAP3K21
MAP7
MBP
MFHAS1
MFSD10
MICU3
MKRN2
MTBP
MTCL1
MYOM1
NCL
NCOR1
NF1
NPM1
NUP153
PATZ1
PDE9A
PHF3
PHLDB2
PIAS4
PIP4K2B
PKD1L1
PLAAT5
PLXDC2
PPFIBP2
PPHLN1
PPIG
PPP1CB
PRDX5
PRKDC
PRMT5
PRPF38A
PRPF4
PRPF4B
PTPN1
PTPN22
RAD21L1
RAPH1
RASL12
RBBP6
RBM15
RBM39
RBMX
REV1
RLF
RPL5
RPS4Y1
RPUSD3
SAFB
SAMD9L
SCARA3
SERPINI2
SF3B1
SFMBT2
SH2B2
SHROOM1
SLC35D3
SLFN5
SPEN
SPTBN4
SRPK1
SRPK2
SRRM1
SRRM2
SRRM4
SRSF1
SRSF10
SRSF3
SRSF5
SRSF6
SRSF7
SSBP3
STIP1
STK31
SVOP
TEX11
THRAP3
THY1
TJP2
TLN2
TMPO
TMPRSS2
TNIP2
TP53RK
TRA2B
UBL5
UNC13B
VWA7
YTHDC1
YWHAG
ZC3H13
ZMYND10
ZNF148
Entrez ID
8396
1195
HPRD ID
04463
09058
Ensembl ID
ENSG00000276293
ENSG00000013441
Uniprot IDs
P78356
P49759
PDB IDs
1BO1
3WZZ
3X01
3X02
3X03
3X04
3X05
3X06
3X07
3X08
3X09
3X0A
3X0B
3X0C
6K4G
6K4H
1Z57
2VAG
5J1V
5J1W
5X8I
6FT8
6FT9
6FYO
6G33
6I5H
6I5I
6I5K
6I5L
6KHD
6Q8K
6Q8P
6QTY
6R3D
6R6E
6R6X
6R8J
6RAA
6TW2
6YTA
6YTD
6YTE
6YTG
6YTI
6Z4Z
6Z50
6ZLN
Enriched GO Terms of Interacting Partners
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