HASPIN and PDS5B

Data Source:
BioGRID (two hybrid)

		HASPIN	PDS5B
Description		histone H3 associated protein kinase	PDS5 cohesin associated factor B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T3 Specific) Protein Serine Kinase Activity Protein Threonine Kinase Activity	DNA Binding Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Mitotic Sister Chromatid Cohesion Intracellular Signal Transduction Protein Localization To Chromosome, Centromeric Region Histone H3-T3 Phosphorylation Involved In Chromosome Passenger Complex Localization To Kinetochore	DNA Repair Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division
Pathways			Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs		5-iodotubercidin 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine H-89 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol
Diseases
GWAS			Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		5 interacting genes: AURKB H3C1 HSF2BP MDFI PDS5B	5 interacting genes: APP BRCA2 HASPIN PALB2 RAD51
Entrez ID		83903	23047
HPRD ID		17083	05624
Ensembl ID		ENSG00000177602	ENSG00000083642
Uniprot IDs		A0PJ70 Q8TF76	Q9NTI5
PDB IDs		2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E	5HDT
Enriched GO Terms of Interacting Partners?
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