PDS5B and HASPIN

Data Source:
BioGRID (two hybrid)

		PDS5B	HASPIN
Description		PDS5 cohesin associated factor B	histone H3 associated protein kinase
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol	Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle
	Molecular Function	DNA Binding Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Histone Kinase Activity (H3-T3 Specific) Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Repair Mitotic Sister Chromatid Cohesion Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Cell Population Proliferation Cell Division	Mitotic Cell Cycle Protein Phosphorylation Mitotic Sister Chromatid Cohesion Intracellular Signal Transduction Protein Localization To Chromosome, Centromeric Region Histone H3-T3 Phosphorylation Involved In Chromosome Passenger Complex Localization To Kinetochore
Pathways		Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion
Drugs			5-iodotubercidin 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine H-89 (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 27611488) Body mass index ( 25673413) Circulating fibroblast growth factor 23 levels ( 30217807) Coronary artery disease ( 29212778 33020668) Logical memory (delayed recall) ( 29274321) Lung cancer ( 28604730) Mean platelet volume ( 27863252) Squamous cell lung carcinoma ( 28604730) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
Interacting Genes		5 interacting genes: APP BRCA2 HASPIN PALB2 RAD51	5 interacting genes: AURKB H3C1 HSF2BP MDFI PDS5B
Entrez ID		23047	83903
HPRD ID		05624	17083
Ensembl ID		ENSG00000083642	ENSG00000177602
Uniprot IDs		Q9NTI5	A0PJ70 Q8TF76
PDB IDs		5HDT	2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E
Enriched GO Terms of Interacting Partners?
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