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HASPIN

Description histone H3 associated protein kinase
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Chromosome
  • Cytoplasm
  • Centrosome
  • Spindle
Molecular Function
  • Protein Kinase Activity
  • Protein Binding
  • ATP Binding
  • Histone Kinase Activity (H3-T3 Specific)
  • Protein Serine Kinase Activity
  • Protein Threonine Kinase Activity
Biological Process
  • Mitotic Cell Cycle
  • Protein Phosphorylation
  • Mitotic Sister Chromatid Cohesion
  • Intracellular Signal Transduction
  • Protein Localization To Chromosome, Centromeric Region
  • Histone H3-T3 Phosphorylation Involved In Chromosome Passenger Complex Localization To Kinetochore
Pathways
Drugs
  • 5-iodotubercidin
  • 3-(3-aminophenyl)-N-(3-chlorophenyl)pyrazolo[1,5-a]pyrimidin-5-amine
  • H-89
  • (2S)-2-{[3-(3-aminophenyl)imidazo[1,2-b]pyridazin-6-yl]amino}-3-methylbutan-1-ol
Diseases
GWAS
Novel Interacting Genes 1 novel interacting genes: ZNF594
Interacting Genes 5 interacting genes: AURKB H3C1 HSF2BP MDFI PDS5B
Entrez ID 83903
HPRD ID 17083
Ensembl ID ENSG00000177602
Uniprot IDs A0PJ70 Q8TF76
PDB IDs 2VUW 2WB8 3DLZ 3E7V 3F2N 3FMD 3IQ7 4OUC 4QTC 5HTB 5HTC 6G34 6G35 6G36 6G37 6G38 6G39 6G3A 6Z56 6Z57 6Z58 6Z59 6Z5A 6Z5B 6Z5C 6Z5D 6Z5E
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025