L3MBTL2 and MEAF6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		L3MBTL2	MEAF6
Description		L3MBTL histone methyl-lysine binding protein 2	MYST/Esa1 associated factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Kinetochore Condensed Chromosome Kinetochore Nucleoplasm Nucleolus NuA4 Histone Acetyltransferase Complex MOZ/MORF Histone Acetyltransferase Complex NuA3a Histone Acetyltransferase Complex NuA3b Histone Acetyltransferase Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Methylated Histone Binding Histone Binding	Protein Binding Histone Acetyltransferase Activity (H3-K23 Specific)
	Biological Process	Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Histone H2A Acetylation Histone H3-K23 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Histone H3-K14 Acetylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6	HATs acetylate histones HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 29255261 27918536) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Eyebrow thickness ( 26926045)
Interacting Genes		49 interacting genes: AMOTL2 BEND7 BHLHB9 BIVM CARD9 CCDC106 CCDC33 CEP76 EFHC2 EIF4ENIF1 FAM217B GAS8 GKAP1 GOLGA2 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829	9 interacting genes: C2CD6 CCDC85B FXR2 JADE2 L3MBTL2 LDOC1 MRGBP PLEKHF2 TRIM54
Entrez ID		83746	64769
HPRD ID		13954	13347
Ensembl ID		ENSG00000100395	ENSG00000163875
Uniprot IDs		A0A0S2Z5X6 Q969R5	Q9HAF1
PDB IDs		2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?
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