RIOK1 and WDR77

Data Source:
BioGRID (pull down)

		RIOK1	WDR77
Description		RIO kinase 1	WD repeat domain 77
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Pole Plasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Hydrolase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Methyl-CpG Binding Nuclear Receptor Coactivator Activity
	Biological Process	Protein Phosphorylation Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing	Spliceosomal SnRNP Assembly Regulation Of Transcription By RNA Polymerase II Pole Plasm Assembly Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transcription, DNA-templated Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	snRNP Assembly RMTs methylate histone arginines
Drugs		Fostamatinib
Diseases
GWAS		Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		7 interacting genes: APP CSNK2A1 FBXO6 KDM1A SETD7 WDR77 YWHAB	44 interacting genes: AQR BAG2 CDK19 CDK8 CLNS1A CREBBP CTDP1 GLI1 GPKOW H2AC21 HNRNPM LSM3 NKX3-1 PCBP2 PPIL1 PPP1R8 PQBP1 PRKG1 PRKG2 PRMT5 QKI RBM5 RIOK1 SAP30BP SF1 SF3A1 SF3B4 SIRT7 SMAD1 SMYD1 SNRPB SNRPC SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SUZ12 THOC1 TOE1 YWHAB YWHAQ ZMYND19 ZNF207
Entrez ID		83732	79084
HPRD ID		17978	14387
Ensembl ID		ENSG00000124784	ENSG00000116455
Uniprot IDs		Q9BRS2	A0A024R0H7 Q9BQA1
PDB IDs		4OTP 6G5I 6V0N	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UXX 6UXY 6V0N 6V0O
Enriched GO Terms of Interacting Partners?
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