CASP4 and NOMO1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study)
HPRD (in vitro, in vivo)

		CASP4	NOMO1
Description		caspase 4	NODAL modulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Cellular_component Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Molecular_function Protein Binding Carbohydrate Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Protein Autoprocessing Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptosis Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta	Biological_process Negative Regulation Of Nodal Signaling Pathway
Pathways		NOD1/2 Signaling Pathway
Drugs		Incadronic acid	Theophylline
Diseases
GWAS		Major depressive disorder ( 29317602)
Interacting Genes		16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	12 interacting genes: ATF7IP BAG6 ECT2 EXOSC10 NCLN SHBG STAT1 TOM1L1 TRIM55 TRIM63 UBQLN4 UPF2
Entrez ID		837	23420
HPRD ID		04047	11398
Ensembl ID		ENSG00000196954	ENSG00000103512
Uniprot IDs		P49662	Q15155
PDB IDs		6KMZ 6NRY
Enriched GO Terms of Interacting Partners?
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