DYNLRB1 and DYNC1I2

Data Source:
BioGRID (two hybrid, affinity chromatography technology, proximity labelling technology, biochemical)

		DYNLRB1	DYNC1I2
Description		dynein light chain roadblock-type 1	dynein cytoplasmic 1 intermediate chain 2
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytoplasmic Dynein Complex Microtubule Cilium Membrane Ciliary Tip	Cytoplasm Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle
	Molecular Function	Microtubule Motor Activity Protein Binding Dynein Intermediate Chain Binding	Microtubule Motor Activity Protein Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Microtubule-based Movement Visual Behavior Intraciliary Transport Involved In Cilium Assembly	G2/M Transition Of Mitotic Cell Cycle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Microtubule-based Movement Regulation Of G2/M Transition Of Mitotic Cell Cycle Transport Along Microtubule Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Ciliary Basal Body-plasma Membrane Docking
Pathways		Intraflagellar transport	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Fish- and plant-related diet ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Pulse pressure ( 30224653)	Hippocampal volume ( 25625606) Metabolite levels ( 23823483) Refractive error ( 32231278) Weight ( 28552196)
Interacting Genes		9 interacting genes: CPEB1 CRCP DYNC1I1 DYNC1I2 HSPH1 MAGEA2 MAGEA2B MPHOSPH6 PALS2	8 interacting genes: CCDC136 DCTN1 DYNLRB1 DYNLT1 DYNLT3 NECAB2 PNN PPFIA1
Entrez ID		83658	1781
HPRD ID		06203	04512
Ensembl ID		ENSG00000125971	ENSG00000077380
Uniprot IDs		B4DFR2 Q9NP97	A0A140VKE9 B4DPZ3 Q13409
PDB IDs		1Z09 2B95 2E8J 2HZ5 6F1T 6F1Z 6F38 6F3A 6RLB 6SC2	5JPW 6F1T 6F1U 6F1Z 6F38 6F3A
Enriched GO Terms of Interacting Partners?
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