ZMIZ2 and PIAS3

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		ZMIZ2	PIAS3
Description		zinc finger MIZ-type containing 2	protein inhibitor of activated STAT 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Nuclear Replication Fork	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse
	Molecular Function	Protein Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription SMAD Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway
Pathways			SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) General cognitive ability ( 29844566) Hematocrit ( 32888494) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 27863252) Red blood cell count ( 27863252)
Interacting Genes		25 interacting genes: AR ARSJ ASB13 BANP C2orf88 CPNE7 CRCP FRS3 GCM2 INTS4 LRRC37A11P MCPH1 MVP NBL1 PIAS3 PIN1 RANBP3 SALL2 SCAMP1 SELENOV SOCS6 SS18L1 SSX2 TP53 TRAPPC6A	55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2
Entrez ID		83637	10401
HPRD ID		13225	09068
Ensembl ID		ENSG00000122515	ENSG00000131788
Uniprot IDs		E7EWM3 Q8NF64	B3KNI3 Q9Y6X2
PDB IDs			4MVT
Enriched GO Terms of Interacting Partners?
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