PIAS3 and SIAH2

Data Source:
BioGRID (pull down)

		PIAS3	SIAH2
Description		protein inhibitor of activated STAT 3	siah E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Nucleoplasm Cytoplasm Early Endosome Cytosol Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	Transcription Corepressor Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Cell Cycle Small GTPase Mediated Signal Transduction Multicellular Organism Development Protein Deubiquitination Regulation Of Protein Ubiquitination Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Netrin-activated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			BRCA1/2-negative high-risk breast cancer ( 30323354) Breast cancer ( 22951594 31757997)
Interacting Genes		55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	43 interacting genes: AFF1 AKR1C3 ATN1 CACYBP CCBE1 CHEK2 DCC DYRK2 EEF1D EGLN3 HIPK2 HIPK3 MYD88 NRF1 OPRM1 PEG10 PEG3 PIAS2 PIAS3 PML POU2AF1 PSMD4 RBBP8 SETD2 SNCA SNCAIP SPRY2 STAT3 SYP TINF2 TP53BP2 TPX2 TRAF2 UBE2D1 UBE2D2 UBE2D3 UBE2I UBE2L6 UBE2N UBE2V2 USP13 USP19 VAV1
Entrez ID		10401	6478
HPRD ID		09068	03737
Ensembl ID		ENSG00000131788	ENSG00000181788
Uniprot IDs		B3KNI3 Q9Y6X2	O43255
PDB IDs		4MVT	5H9M
Enriched GO Terms of Interacting Partners?
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