PIAS3 and ZMIZ1

Data Source:
BioGRID (two hybrid)

		PIAS3	ZMIZ1
Description		protein inhibitor of activated STAT 3	zinc finger MIZ-type containing 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	Transcription Coactivator Activity Zinc Ion Binding Nuclear Receptor Coactivator Activity SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Vasculogenesis In Utero Embryonic Development Heart Morphogenesis Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Vitellogenesis Cell Aging Pyramidal Neuron Migration Androgen Receptor Signaling Pathway Regulation Of Protein Sumoylation Positive Regulation Of T Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin-mediated Maintenance Of Transcription Positive Regulation Of Fibroblast Proliferation Developmental Growth Artery Morphogenesis SMAD Protein Signal Transduction Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Adult body size ( 32376654) Ankylosing spondylitis ( 23749187) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Autoimmune traits (pleiotropy) ( 30572963) Bipolar disorder ( 20351715) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 23535729 20453838) Brown vs. black hair color ( 30531825) Celiac disease ( 22057235 20190752 25920553 30572963) Ceramide levels (C24:0) ( 32489964) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cobalt levels ( 26025379) Colorectal cancer ( 30529582 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 25489960 28067908 21102463) Crohn's disease and psoriasis ( 22482804) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Height ( 25282103 25429064 23563607 31562340) High density lipoprotein cholesterol levels ( 31928498) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Mean platelet volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 22190364 24076602 19525953 21833088) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet distribution width ( 32888494 27863252) PR interval ( 32439900) Prostate cancer ( 31562322) Psoriasis ( 25854761 23143594) Psoriasis vulgaris ( 26626624) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) TPE interval (resting) ( 32386560) Triiodothyronine/thyroxine ratio ( 30824882) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 31118516 32499647 30718926 28869590) Urate levels ( 31578528) Vitiligo ( 20526339) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	5 interacting genes: AR CACHD1 CNTNAP2 PIAS3 TBC1D4
Entrez ID		10401	57178
HPRD ID		09068	12115
Ensembl ID		ENSG00000131788	ENSG00000108175
Uniprot IDs		B3KNI3 Q9Y6X2	A0A024QZN6 A0JLS3 Q9ULJ6
PDB IDs		4MVT	5AIZ
Enriched GO Terms of Interacting Partners?
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