NOD1 and CASP4

Data Source:
HPRD (in vivo)

		NOD1	CASP4
Description		nucleotide binding oligomerization domain containing 1	caspase 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane Phagocytic Vesicle Anchored Component Of Plasma Membrane	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Activation Of MAPK Activity Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Positive Regulation Of Cell Death Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Xenophagy	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Protein Autoprocessing Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptosis Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling	NOD1/2 Signaling Pathway
Drugs			Incadronic acid
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Knee osteoarthritis ( 27696742) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Major depressive disorder ( 29317602)
Interacting Genes		13 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		10392	837
HPRD ID		05815	04047
Ensembl ID		ENSG00000106100	ENSG00000196954
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239	P49662
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW	6KMZ 6NRY
Enriched GO Terms of Interacting Partners?
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