RAB33B and RABGEF1

Data Source:
HPRD (in vitro)

		RAB33B	RABGEF1
Description		RAB33B, member RAS oncogene family	RAB guanine nucleotide exchange factor 1
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GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Golgi Lumen	Nucleolus Early Endosome Cytosol Early Endosome Membrane Recycling Endosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding	DNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Small GTPase Binding
	Biological Process	Regulation Of Cell Growth Intra-Golgi Vesicle-mediated Transport Autophagy Protein Transport Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Golgi Organization Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER	Protein Targeting To Membrane Endocytosis Regulation Of Catalytic Activity
Pathways		Intra-Golgi traffic TBC/RABGAPs RAB geranylgeranylation	TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Aortic root size ( 21223598) Central corneal thickness ( 32528159 29760442)
Interacting Genes		12 interacting genes: ACVR1 ATG16L1 ATG16L2 ATG5 CCDC136 GOLGA2 RABEP1 RABGEF1 RUFY2 SIAH1 TGFBR1 USP6	50 interacting genes: ABI2 ANKRD29 AP1G1 ARRDC3 BLOC1S6 CCHCR1 CDC37 CIPC DAZAP2 DCTN2 DGCR6 DNAJC5 EMILIN1 GGA1 GGA2 GPRASP2 HOOK2 HRAS IHO1 KXD1 MID2 MON1A MON1B OIP5 RAB33B RAB4A RABEP1 RAD23A RASAL3 RNF11 RNF168 RPS27A SESTD1 SNAPIN SPART SSX3 TCHP TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBA52 UBB UBC UBE2D1 UBE2D3 WASHC1 YWHAB ZC2HC1C
Entrez ID		83452	27342
HPRD ID		05808	11477
Ensembl ID		ENSG00000172007	ENSG00000154710
Uniprot IDs		A0A494C0Z5 Q9H082	A0A024RDL6 A8K3R3 B3KMF1 Q9UJ41
PDB IDs		6Y09 6ZAY	1TXU 2C7M 2C7N 2OT3 4N3X 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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