KDM5D and PCGF6

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		KDM5D	PCGF6
Description		lysine demethylase 5D	polycomb group ring finger 6
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Metal Ion Binding Androgen Receptor Binding Dioxygenase Activity	Protein Binding Metal Ion Binding
	Biological Process	Chromatin Remodeling Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Regulation Of Androgen Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways		HDMs demethylate histones	Transcriptional Regulation by E2F6
Drugs		Ascorbic acid
Diseases
GWAS		Autism ( 32996047)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		2 interacting genes: H3-4 PCGF6	26 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RING1 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21
Entrez ID		8284	84108
HPRD ID		02464	07427
Ensembl ID		ENSG00000012817	ENSG00000156374
Uniprot IDs		A0A384MR42 Q9BY66	Q9BYE7
PDB IDs		2E6R 2YQE	2DJB
Enriched GO Terms of Interacting Partners?
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