PCGF6 and PEX10

Data Source:
BioGRID (two hybrid)

		PCGF6	PEX10
Description		polycomb group ring finger 6	peroxisomal biogenesis factor 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Peroxisome Peroxisomal Membrane
	Molecular Function	Protein Binding Metal Ion Binding	Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination
Pathways		Transcriptional Regulation by E2F6	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)	Body mass index ( 26426971) Non-obstructive azoospermia ( 22197933)
Interacting Genes		26 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RING1 RNF2 SS18L1 TRIM14 TRIM55 TRIM63 TULP3 UBE2D3 UBE2U USP2 USP21	10 interacting genes: CGRRF1 HNRNPD LIG4 MKRN3 PCGF6 PEX12 PEX19 PEX2 PEX5 UBE2I
Entrez ID		84108	5192
HPRD ID		07427	04175
Ensembl ID		ENSG00000156374	ENSG00000157911
Uniprot IDs		Q9BYE7	A0A024R068 A0A024R0A4 O60683
PDB IDs		2DJB
Enriched GO Terms of Interacting Partners?
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