WNK2 and ESS2

Data Source:
BioGRID (two hybrid)

		WNK2	ESS2
Description		WNK lysine deficient protein kinase 2	ess-2 splicing factor homolog
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Molecular_function Protein Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Sodium Ion Transport Intracellular Signal Transduction Protein Autophosphorylation Ion Homeostasis Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Transmembrane Transporter Activity	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways		Stimuli-sensing channels
Drugs
Diseases
GWAS		Ability to confide in someone ( 29970889) Bipolar disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Perceived sweetness of sucrose ( 31005972)
Interacting Genes		5 interacting genes: ATXN1 ESS2 MTDH WNK1 YWHAZ	18 interacting genes: ARMC7 CCDC57 CDK5RAP3 CRP DGCR6 DHX16 EXOC8 FRA10AC1 LYST OIP5 PFDN1 QARS1 RACK1 RBM4 SMARCD1 TTC14 VIM WNK2
Entrez ID		65268	8220
HPRD ID		06951	03452
Ensembl ID		ENSG00000165238	ENSG00000100056
Uniprot IDs		F8W9F9 Q9Y3S1	F8WEF8 Q96DF8
PDB IDs		6ELM 6FBK
Enriched GO Terms of Interacting Partners?
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