ABHD17A and GPC4

Data Source:
BioGRID (two hybrid)

		ABHD17A	GPC4
Description		abhydrolase domain containing 17A, depalmitoylase	glypican 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endosome Membrane Membrane Nuclear Speck Dendritic Spine Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Glutamatergic Synapse Anchored Component Of Postsynaptic Density Membrane Anchored Component Of Postsynaptic Recycling Endosome Membrane	Nucleus Golgi Lumen Plasma Membrane External Side Of Plasma Membrane Cell Surface Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Glutamatergic Synapse Anchored Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Palmitoyl-(protein) Hydrolase Activity	Protein Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Protein Depalmitoylation Protein Phosphopantetheinylation Protein Localization To Membrane Regulation Of Postsynapse Organization Negative Regulation Of Protein Localization To Microtubule Positive Regulation Of Protein Localization To Endosome	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Signal Transduction Wnt Signaling Pathway Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Synaptic Membrane Adhesion Regulation Of Protein Localization To Membrane Regulation Of Presynapse Assembly
Pathways		RAS processing	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS
Interacting Genes		13 interacting genes: BIRC2 EHMT2 GOLGA2 GPC4 HPGDS KRTAP5-9 MDFI PLSCR4 PNMA1 RGS20 TNIP1 TRAF1 TRIM27	10 interacting genes: ABHD17A ACP5 AKAP9 CCNC COL18A1 FGF2 PICK1 PTEN PTPRD PTPRF
Entrez ID		81926	2239
HPRD ID		07475	02160
Ensembl ID		ENSG00000129968	ENSG00000076716
Uniprot IDs		Q96GS6	O75487
PDB IDs
Enriched GO Terms of Interacting Partners?
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