SH3GL3 and EGFL6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SH3GL3	EGFL6
Description		SH3 domain containing GRB2 like 3, endophilin A3	EGF like domain multiple 6
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Basement Membrane Extracellular Space Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding	Integrin Binding Calcium Ion Binding Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis	Cell Adhesion Multicellular Organism Development Positive Regulation Of Cell-substrate Adhesion Cell Differentiation Extracellular Matrix Organization
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Spine bone size ( 31053729) Working memory ( 31598132)	Acute post-radiotherapy pain in breast cancer ( 31196165) Multiple sclerosis ( 23412934)
Interacting Genes		51 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	3 interacting genes: SH3GL2 SH3GL3 UBQLN2
Entrez ID		6457	25975
HPRD ID		04528	02212
Ensembl ID		ENSG00000140600	ENSG00000198759
Uniprot IDs		A0A024R215 Q99963	Q8IUX8
PDB IDs		2EW3 2Z0V
Enriched GO Terms of Interacting Partners?
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