SPRY4 and KRTAP5-11

Data Source:
BioGRID (two hybrid)

		SPRY4	KRTAP5-11
Description		sprouty RTK signaling antagonist 4	keratin associated protein 5-11
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Ruffle Membrane	Cytosol Keratin Filament
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Keratinization
Pathways			Keratinization
Drugs
Diseases
GWAS		Asthma ( 31959851 29273806) Body mass index ( 28552196) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Inflammatory bowel disease ( 23128233) Physiological traits ( 31902109) Systolic blood pressure ( 30578418) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)
Interacting Genes		17 interacting genes: ADAM12 COL8A1 CREB5 EFEMP2 FHL2 HOXA1 KLHL38 KRTAP5-11 NUTF2 OTX1 POU4F2 RAF1 RIN3 TESK1 TNS2 VENTX ZDHHC17	58 interacting genes: CATSPER1 CRCT1 CREB5 CYSRT1 FAM76B GLRX3 GORASP2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-4 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NECTIN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 POU4F2 RGS17 RGS20 SH3GLB2 SMCP SPRY4 TMEM190 TRIM42 VASN VGLL3
Entrez ID		81848	440051
HPRD ID		10466	17248
Ensembl ID		ENSG00000187678	ENSG00000204571
Uniprot IDs		A0A0C4DFS6 Q9C004	Q6L8G4
PDB IDs		3BUN
Enriched GO Terms of Interacting Partners?
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