NECTIN4 and TIGIT

		NECTIN4	TIGIT
Description		nectin cell adhesion molecule 4	T cell immunoreceptor with Ig and ITIM domains
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GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Enfortumab vedotin
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT	6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR
Entrez ID		81607	201633
HPRD ID		17934	08804
Ensembl ID		ENSG00000143217	ENSG00000181847
Uniprot IDs		K4PZ75 Q96NY8	Q495A1
PDB IDs		4FRW 4GJT 4JJH	3Q0H 3RQ3 3UCR 3UDW 5V52
Enriched GO Terms of Interacting Partners?
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