TIGIT and NECTIN4

		TIGIT	NECTIN4
Description		T cell immunoreceptor with Ig and ITIM domains	nectin cell adhesion molecule 4
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Integral Component Of Membrane	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Virus Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-10 Production Negative Regulation Of T Cell Activation	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell
Pathways			Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs			Enfortumab vedotin
Diseases			Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS
Interacting Genes		6 interacting genes: MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR	6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		201633	81607
HPRD ID		08804	17934
Ensembl ID		ENSG00000181847	ENSG00000143217
Uniprot IDs		Q495A1	K4PZ75 Q96NY8
PDB IDs		3Q0H 3RQ3 3UCR 3UDW 5V52	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?
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