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TIGIT and NECTIN2
Data Source:
BioGRID
(pull down)
TIGIT
NECTIN2
Description
T cell immunoreceptor with Ig and ITIM domains
nectin cell adhesion molecule 2
Image
GO Annotations
Cellular Component
Plasma Membrane
Cell Surface
Integral Component Of Membrane
Plasma Membrane
Cell-cell Junction
Zonula Adherens
Focal Adhesion
Cell Surface
Integral Component Of Membrane
Apical Junction Complex
Cell-cell Contact Zone
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Protein Binding
Identical Protein Binding
Virus Receptor Activity
Protein Binding
Coreceptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Cell Adhesion Molecule Binding
Biological Process
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-10 Production
Negative Regulation Of T Cell Activation
Acrosome Assembly
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Positive Regulation Of Immunoglobulin Mediated Immune Response
Cytoskeleton Organization
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Spermatid Development
Spermatid Nucleus Differentiation
Fertilization
Fusion Of Virus Membrane With Host Plasma Membrane
Sperm Mitochondrion Organization
Cell Part Morphogenesis
Positive Regulation Of Mast Cell Activation
Adherens Junction Organization
Susceptibility To Natural Killer Cell Mediated Cytotoxicity
Adhesion Of Symbiont To Host
Cilium Organization
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Regulation Of Viral Entry Into Host Cell
Coreceptor-mediated Virion Attachment To Host Cell
Regulation Of Immune Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Establishment Of Mitochondrion Localization
Susceptibility To T Cell Mediated Cytotoxicity
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Adherens junctions interactions
Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS
Emphysema annual change measurement in smokers (percent low attenuation area) (
31324189
)
Low density lipoprotein cholesterol levels (
30498476
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Triglyceride levels x long total sleep time interaction (2df test) (
31719535
)
Triglyceride levels x short total sleep time interaction (2df test) (
31719535
)
Urate levels (
31578528
)
Interacting Genes
6 interacting genes:
MAL
NECTIN2
NECTIN3
NECTIN4
PLLP
PVR
36 interacting genes:
AFDN
ATP5MF
CD226
CYSRT1
DUS2
HOXA1
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP12-2
KRTAP5-9
LCE1C
LCE2B
LCE2C
LCE5A
LYRM4
MAPK6
MDFI
MEOX2
NBPF19
NECTIN3
NECTIN4
NOTCH2NLA
NR4A3
P4HB
PICK1
RGS20
SIAH1
TCF4
TGM1
TIGIT
USP53
Entrez ID
201633
5819
HPRD ID
08804
02879
Ensembl ID
ENSG00000181847
ENSG00000130202
Uniprot IDs
Q495A1
Q92692
PDB IDs
3Q0H
3RQ3
3UCR
3UDW
5V52
3R0N
4DFH
4DFI
4HZA
5V52
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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