PLA2G12A and RPS6

Data Source:
BioGRID (two hybrid)

		PLA2G12A	RPS6
Description		phospholipase A2 group XIIA	ribosomal protein S6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Nucleus Nucleoplasm Nucleolus Endoplasmic Reticulum Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	RNA Binding Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Biological_process Lipid Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Gastrulation Positive Regulation Of Cell Population Proliferation Viral Transcription Mammalian Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Erythrocyte Development
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation mTORC1-mediated signalling SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Artenimol
Diseases
GWAS		Blood protein levels ( 28240269) HDL cholesterol ( 30275531) Mean spheric corpuscular volume ( 32888494) Triglycerides ( 30275531)	Total cholesterol levels ( 29083408)
Interacting Genes		8 interacting genes: DVL2 MEF2C RB1 RPS15 RPS6 TMEM37 UMPS YWHAG	16 interacting genes: ATF4 DUX4 ERCC6 FRS2 MYOM2 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH PTEN RPS6KB1 RPS6KB2 STAU1 UPF2
Entrez ID		81579	6194
HPRD ID		17858	01592
Ensembl ID		ENSG00000123739	ENSG00000137154
Uniprot IDs		Q542Y6 Q9BZM1	A2A3R6 P62753
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6F4P 6F4Q 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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