PLA2G12A and RPS15

Data Source:
BioGRID (two hybrid)

		PLA2G12A	RPS15
Description		phospholipase A2 group XIIA	ribosomal protein S15
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Nucleus Nucleoplasm Cytosol Focal Adhesion Membrane Cytosolic Small Ribosomal Subunit
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	DNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Phosphatidic Acid Biosynthetic Process Biological_process Lipid Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Arachidonic Acid Secretion	Ribosomal Small Subunit Assembly Ribosomal Small Subunit Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Osteoblast Differentiation RRNA Processing Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Ribosomal Small Subunit Biogenesis
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) HDL cholesterol ( 30275531) Mean spheric corpuscular volume ( 32888494) Triglycerides ( 30275531)	Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		8 interacting genes: DVL2 MEF2C RB1 RPS15 RPS6 TMEM37 UMPS YWHAG	11 interacting genes: CDC42 DUX4 ERCC6 G2E3 NAP1L1 PLA2G12A PTEN RAPGEF1 RPS4X SERINC3 UPF2
Entrez ID		81579	6209
HPRD ID		17858	01613
Ensembl ID		ENSG00000123739	ENSG00000115268
Uniprot IDs		Q542Y6 Q9BZM1	K7ELC2 P62841
PDB IDs			4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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