ZBP1 and PALD1

Data Source:
BioGRID (pull down)

		ZBP1	PALD1
Description		Z-DNA binding protein 1	phosphatase domain containing paladin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	DNA Binding Left-handed Z-DNA Binding Double-stranded RNA Binding Protein Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Activation Of Innate Immune Response Apoptotic Process Viral Process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Necroptotic Process Pyroptosis Regulation Of Interleukin-1-mediated Signaling Pathway	Peptidyl-tyrosine Dephosphorylation
Pathways		ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA Potential therapeutics for SARS
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)	Lymphocyte percentage of white cells ( 27863252) Superior frontal gyrus volume ( 31530798) Type 2 diabetes ( 30130595)
Interacting Genes		8 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6	2 interacting genes: IRF7 ZBP1
Entrez ID		81030	27143
HPRD ID		09484	11419
Ensembl ID		ENSG00000124256	ENSG00000107719
Uniprot IDs		Q9H171	A0A024QZM5 Q9ULE6
PDB IDs		2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?
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