PALD1 and ZBP1

Data Source:
BioGRID (pull down)

		PALD1	ZBP1
Description		phosphatase domain containing paladin 1	Z-DNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	DNA Binding Left-handed Z-DNA Binding Double-stranded RNA Binding Protein Binding
	Biological Process	Peptidyl-tyrosine Dephosphorylation	Activation Of Innate Immune Response Apoptotic Process Viral Process Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Necroptotic Process Pyroptosis Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways			ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA Potential therapeutics for SARS
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 27863252) Superior frontal gyrus volume ( 31530798) Type 2 diabetes ( 30130595)	Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: IRF7 ZBP1	8 interacting genes: CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6
Entrez ID		27143	81030
HPRD ID		11419	09484
Ensembl ID		ENSG00000107719	ENSG00000124256
Uniprot IDs		A0A024QZM5 Q9ULE6	Q9H171
PDB IDs			2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?
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