APOL6 and LAMTOR3

Data Source:
BioGRID (two hybrid)

		APOL6	LAMTOR3
Description		apolipoprotein L6	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex
	Molecular Function	Protein Binding Lipid Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity
	Biological Process	Lipid Transport Lipoprotein Metabolic Process	MAPK Cascade Activation Of MAPKK Activity Cell Cycle Arrest Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction
Pathways			Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Mean reticulocyte volume ( 32888494)
Interacting Genes		10 interacting genes: ADAMTSL4 CCN3 FNTB GMCL1 KPNA3 KRTAP10-8 LAMTOR3 MTNR1B RGS13 TEPSIN	20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4
Entrez ID		80830	8649
HPRD ID		06266	04485
Ensembl ID		ENSG00000221963	ENSG00000109270
Uniprot IDs		B3KTP4 Q9BWW8	Q9UHA4
PDB IDs			1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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