APOL6 and FNTB

Data Source:
BioGRID (two hybrid)

		APOL6	FNTB
Description		apolipoprotein L6	farnesyltransferase, CAAX box, beta
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm	Cytosol Microtubule Associated Complex Protein Farnesyltransferase Complex
	Molecular Function	Protein Binding Lipid Binding	Protein Farnesyltransferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Lipid Transport Lipoprotein Metabolic Process	Protein Phosphopantetheinylation Protein Prenylation Protein Farnesylation Regulation Of Rhodopsin Mediated Signaling Pathway
Pathways			Inactivation, recovery and regulation of the phototransduction cascade RAS processing
Drugs			AZD3409 Tipifarnib Lonafarnib 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE L-778123 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID Farnesyl diphosphate Geranylgeranyl diphosphate ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
Diseases
GWAS		HDL cholesterol levels ( 32203549) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood trace element (Zn levels) ( 23720494) Eosinophil counts ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494 27863252 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252 28017375 19862010) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		10 interacting genes: ADAMTSL4 CCN3 FNTB GMCL1 KPNA3 KRTAP10-8 LAMTOR3 MTNR1B RGS13 TEPSIN	17 interacting genes: AGXT APOL6 ATPAF2 CCDC24 CENPF FNTA GBP1 HDAC6 HOXC8 HRAS KRAS KRBA1 PTP4A3 RAP2A RRAS2 SMG9 TLX3
Entrez ID		80830	2342
HPRD ID		06266	00608
Ensembl ID		ENSG00000221963	ENSG00000257365
Uniprot IDs		B3KTP4 Q9BWW8	A0A384MEJ5 P49356
PDB IDs			1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37
Enriched GO Terms of Interacting Partners?
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