LAMTOR3 and PDE4DIP

Data Source:
BioGRID (two hybrid)

		LAMTOR3	PDE4DIP
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	phosphodiesterase 4D interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Endosome Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Ragulator Complex	Nucleus Cytoplasm Golgi Apparatus Centrosome Myofibril
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Activator Activity Molecular Adaptor Activity	Protein Binding Enzyme Binding Molecular Adaptor Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity Cell Cycle Arrest Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Cellular Protein Localization Neutrophil Degranulation Cellular Response To Amino Acid Stimulus Protein Localization To Cell Junction	Cellular Protein-containing Complex Assembly Regulation Of Golgi Organization
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes MAP2K and MAPK activation Neutrophil degranulation Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494)	Capecitabine sensitivity ( 22864933)
Interacting Genes		20 interacting genes: ADAMTS10 APOL6 BHMT CEBPZ CPNE6 IBTK LAMTOR2 MAP2K1 MAP2K2 MAPK1 MAPK3 MBD2 NIF3L1 PDE4DIP QARS1 SUFU TFE3 TGM7 UBR1 ZSCAN4	85 interacting genes: ADH1B AEN AKTIP ANKRD11 ARNT2 BYSL C1orf109 CCDC146 CCDC198 CDC5L CDKN1A CHCHD3 CLIP4 CWF19L2 EGR2 FAM161A FAM50B FAM74A4 FCHSD2 FES FHL1 GADD45G GFI1B GOLGA8EP GOLGA8F HAUS1 HOXB5 HOXC8 ITSN2 KDM1A KLC3 KLC4 KRAS KRT18 KRT31 LAMTOR3 LENG1 LIN37 LMO4 MAPRE3 MIF4GD MTUS2 MYBPC2 MYOM1 NAA10 NEFL NEK2 OSGEP PDE4D PEA15 PFDN1 PIAS4 PPP1R18 PRNP PRPF31 PYGM RTP5 SCNM1 SDCBP SH2D4A SHFL SMN1 SNCA TEAD4 TFIP11 TK1 TNIK TRAF4 TULP3 UTP14C VAC14 ZBTB24 ZBTB38 ZBTB4 ZFYVE21 ZKSCAN3 ZNF124 ZNF408 ZNF410 ZNF414 ZNF512B ZNF581 ZNF587 ZNF696 ZSCAN26
Entrez ID		8649	9659
HPRD ID		04485	10482
Ensembl ID		ENSG00000109270	ENSG00000178104
Uniprot IDs		Q9UHA4	A0A075B749 A0A087WYE4 Q5VU43
PDB IDs		1SKO 2ZL1 3CPT 5X6U 5X6V 5Y39 5Y3A 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3
Enriched GO Terms of Interacting Partners?
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