Description |
farnesyltransferase, CAAX box, beta |
HRas proto-oncogene, GTPase |
Image |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- AZD3409
- Tipifarnib
- Lonafarnib
- 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
- (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
- L-778123
- [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
- Farnesyl diphosphate
- Geranylgeranyl diphosphate
- ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
- (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
- (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
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Diseases |
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GWAS |
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Interacting Genes |
17 interacting genes:
AGXT
APOL6
ATPAF2
CCDC24
CENPF
FNTA
GBP1
HDAC6
HOXC8
HRAS
KRAS
KRBA1
PTP4A3
RAP2A
RRAS2
SMG9
TLX3
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146 interacting genes:
ABR
ACTG1
AFDN
AGTR1
ANAPC1
ANKRD11
ANKRD16
ANKRD23
ANKRD34B
APBB1IP
ARAF
ARFGAP1
ARHGAP10
ARHGAP29
ARHGEF1
ARHGEF18
BCL2
BLID
BMPR1A
BRAF
BRAP
BUB1
CAV1
CDC123
CDC25A
CDC25C
CDH1
CDKN2A
CTNNA1
CXCL1
DEAF1
DGKE
DGKZ
DPP9
EIF3L
ERBB2
FBXW7
FNTA
FNTB
FYN
GPSM2
GPSM3
GRB2
GREB1
GRIN1
GRIN2D
HECTD1
HSPA12A
HSPA1L
ICMT
IKZF3
IL1RL1
IL24
IL3
INSR
IRAK1
IRAK2
ITGB3
ITSN1
KRAS
KRT17
KRT18
LGALS1
LZTR1
MAP2K1
MAP2K6
MAP3K6
MAPK10
MAPK8
MLH3
MSH2
MSH6
MTOR
MUTYH
NF1
NRAS
PDE4D
PDE6D
PDGFB
PDGFRL
PI4K2A
PIK3CA
PIK3CD
PIK3CG
PIK3R1
PLA2G4B
PLAAT4
PLCE1
PLCH2
PRKCI
PRKCZ
PRSS50
PTPRJ
QPCT
RAB5C
RABAC1
RABGEF1
RAF1
RALGDS
RAP1B
RAP1GDS1
RAPGEF1
RASA1
RASA2
RASA4
RASGRF1
RASGRP1
RASGRP4
RASIP1
RASSF1
RASSF2
RASSF5
RGL1
RGL2
RGL4
RGS12
RHOD
RIN1
RIT2
RNF115
RSPO3
SHOC2
SMAD4
SNRPE
SNX14
SNX17
SOS1
SOS2
SRC
STK11
STK38
TIAM1
TLR2
TLR6
TLR9
TP73
TTC1
TTC21A
TTC28
UBE3B
UBE4B
USP29
USP42
VAV1
ZBTB10
ZBTB12
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Entrez ID |
2342 |
3265 |
HPRD ID |
00608 |
01813 |
Ensembl ID |
ENSG00000257365
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ENSG00000174775
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Uniprot IDs |
A0A384MEJ5
P49356
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P01112
X5D945
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PDB IDs |
1JCQ
1LD7
1LD8
1MZC
1S63
1SA4
1TN6
2F0Y
2H6F
2H6G
2H6H
2H6I
2IEJ
3E37
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121P
1AA9
1AGP
1BKD
1CLU
1CRP
1CRQ
1CRR
1CTQ
1GNP
1GNQ
1GNR
1HE8
1IAQ
1IOZ
1JAH
1JAI
1K8R
1LF0
1LF5
1LFD
1NVU
1NVV
1NVW
1NVX
1P2S
1P2T
1P2U
1P2V
1PLJ
1PLK
1PLL
1Q21
1QRA
1RVD
1WQ1
1XCM
1XD2
1XJ0
1ZVQ
1ZW6
221P
2C5L
2CE2
2CL0
2CL6
2CL7
2CLC
2CLD
2EVW
2GDP
2LCF
2LWI
2N42
2N46
2Q21
2QUZ
2RGA
2RGB
2RGC
2RGD
2RGE
2RGG
2UZI
2VH5
2X1V
3DDC
3I3S
3K8Y
3K9L
3K9N
3KKM
3KKN
3KUD
3L8Y
3L8Z
3LBH
3LBI
3LBN
3LO5
3OIU
3OIV
3OIW
3RRY
3RRZ
3RS0
3RS2
3RS3
3RS4
3RS5
3RS7
3RSL
3RSO
3TGP
421P
4DLR
4DLS
4DLT
4DLU
4DLV
4DLW
4DLX
4DLY
4DLZ
4DST
4DSU
4EFL
4EFM
4EFN
4G0N
4G3X
4K81
4L9S
4L9W
4NYI
4NYJ
4NYM
4Q21
4RSG
4URU
4URV
4URW
4URX
4URY
4URZ
4US0
4US1
4US2
4XVQ
4XVR
521P
5B2Z
5B30
5E95
5P21
5VBE
5VBZ
5WDO
5WDP
5WDQ
5WFO
5WFP
5WFQ
5WFR
5WPL
5X9S
5ZC6
621P
6AMB
6AXG
6BVI
6BVJ
6BVK
6BVL
6BVM
6CUO
6CUP
6CUR
6D55
6D56
6D59
6D5E
6D5G
6D5H
6D5J
6D5L
6D5M
6D5V
6D5W
6DZH
6E6C
6E6P
6MQT
6NTC
6NTD
6Q21
6V94
6V9F
6V9J
6V9L
6V9M
6V9N
6ZJ0
6ZL3
721P
7JHP
821P
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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