DUSP16 and MAPK11

Data Source:
HPRD (in vitro)

		DUSP16	MAPK11
Description		dual specificity phosphatase 16	mitogen-activated protein kinase 11
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Inactivation Of MAPK Activity Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation MAPK Export From Nucleus MAPK Phosphatase Export From Nucleus, Leptomycin B Sensitive	Activation Of MAPK Activity Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy Signaling by MAPK mutants	NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs			Minocycline KC706 Regorafenib
Diseases
GWAS		Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)	Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		10 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 TRIM54	27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		80824	5600
HPRD ID		09525	04208
Ensembl ID		ENSG00000111266	ENSG00000185386
Uniprot IDs		A0A024RAR2 Q9BY84	Q15759
PDB IDs		2VSW 3TG3 4YR8	3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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