MAPK11 and DUSP10

Data Source:
HPRD (in vitro)

		MAPK11	DUSP10
Description		mitogen-activated protein kinase 11	dual specificity phosphatase 10
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity JUN Kinase Binding Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Phosphatase Activity Mitogen-activated Protein Kinase P38 Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator	Inactivation Of MAPK Activity Regulation Of Adaptive Immune Response Protein Dephosphorylation Negative Regulation Of Epithelial Cell Migration Dephosphorylation Negative Regulation Of Cell Migration Response To Lipopolysaccharide Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Negative Regulation Of JUN Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of JNK Cascade Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Brown Fat Cell Differentiation Negative Regulation Of P38MAPK Cascade Negative Regulation Of Epithelium Regeneration Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs		Minocycline KC706 Regorafenib
Diseases
GWAS		Acne (severe) ( 24927181) Adult body size ( 32376654)	Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Colorectal cancer ( 25990418 20972440 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Copper levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Progressive supranuclear palsy ( 30089514) Serum thyroid-stimulating hormone levels ( 25436638) Tonsillectomy ( 27182965 28928442) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1	20 interacting genes: CMTM6 ERBB4 FHL2 FN1 FNDC3B HOXA1 HTT IGF1R KRTAP3-2 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 PTK7 ROR2 RPS11 SLX1B SNX2
Entrez ID		5600	11221
HPRD ID		04208	12320
Ensembl ID		ENSG00000185386	ENSG00000143507
Uniprot IDs		Q15759	Q9Y6W6
PDB IDs		3GC8 3GC9 3GP0	1ZZW 2OUC 2OUD 3TG1 6MC1
Enriched GO Terms of Interacting Partners?
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