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CEP44 and PSMD3
Data Source:
BioGRID
(two hybrid)
CEP44
PSMD3
Description
centrosomal protein 44
proteasome 26S subunit, non-ATPase 3
Image
No pdb structure
GO Annotations
Cellular Component
Spindle Pole
Cytoplasm
Centrosome
Centriole
Midbody
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Lid Subcomplex
Membrane
Proteasome Accessory Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Binding
Microtubule Binding
Protein Binding
Enzyme Regulator Activity
Biological Process
Centrosome Cycle
Centriole Replication
Centriole-centriole Cohesion
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Post-translational Protein Modification
Regulation Of Catalytic Activity
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Neutrophil degranulation
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Asthma (
31619474
)
Bipolar disorder (
31043756
)
Creatine kinase levels (
29403010
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Mitochondrial DNA copy number (
30704525
)
Monocyte percentage of white cells (
32888494
)
Neutrophil count (
25096241
20172861
29066854
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (
25096241
29403010
22037903
20139978
21738480
)
White blood cell count (basophil) (
27863252
)
White blood cell count (neutrophil) (
28158719
)
White blood cell types (
21738478
)
Interacting Genes
54 interacting genes:
ABI2
ABI3
ANKRD11
AQP1
BEND7
BFSP2
BLOC1S6
BYSL
CAB39
CBY2
CCDC116
CCDC146
CCDC185
CDC23
CENPP
CEP57L1
CHIC2
DCTN2
DHX57
DIP2A
ERAL1
FAM161A
FAM74A4
FXR2
GNG11
H2AP
HAUS1
ING5
KIAA0930
LINC02363
LMO1
LRRFIP1
MAPK9
MCRS1
MLLT6
MRFAP1L1
NAA10
PLEKHF2
POLR3C
POP5
PSMD3
RBM15
RECK
RNF8
SCNM1
TCEA2
TRIM41
TSGA10
TXLNA
ZFYVE26
ZNF250
ZNF417
ZNF587
ZNF688
15 interacting genes:
BLM
CDC42
CEP44
ERBB2
NFKBIA
PRPF3
PSMA6
PSMD1
PSMD6
PSMD7
PTEN
SEM1
TMEM14B
UBC
ZBTB43
Entrez ID
80817
5709
HPRD ID
13885
10170
Ensembl ID
ENSG00000164118
ENSG00000108344
Uniprot IDs
Q9C0F1
O43242
PDB IDs
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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