ADAM12 and TUBGCP2

Data Source:
BioGRID (affinity chromatography technology)

		ADAM12	TUBGCP2
Description		ADAM metallopeptidase domain 12	tubulin gamma complex associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Spindle Pole Equatorial Microtubule Organizing Center Gamma-tubulin Complex Nucleoplasm Centrosome Microtubule Organizing Center Cytosol Cytoplasmic Microtubule Gamma-tubulin Small Complex Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Protein Binding Gamma-tubulin Binding Microtubule Minus-end Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis	Mitotic Cell Cycle Neuron Migration Microtubule Nucleation Brain Development Cytoplasmic Microtubule Organization Spindle Assembly Meiotic Cell Cycle Protein-containing Complex Assembly
Pathways		Signaling by EGFR Invadopodia formation	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)	Mild influenza (H1N1) infection ( 26379185) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1	3 interacting genes: KIF14 PCNT UBC
Entrez ID		8038	10844
HPRD ID		04092	18245
Ensembl ID		ENSG00000148848	ENSG00000130640
Uniprot IDs		A8K6G4 O43184 U5NE98	Q53EQ3 Q9BSJ2
PDB IDs			6V6B 6V6S 6X0V
Enriched GO Terms of Interacting Partners?
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