TRIM45 and UBE2B

Data Source:
BioGRID (pull down)

		TRIM45	UBE2B
Description		tripartite motif containing 45	ubiquitin conjugating enzyme E2 B
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytosol Intercellular Bridge	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Bone Development	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Heterochromatin Maintenance Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Interferon gamma signaling	Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
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Diseases
GWAS			Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		17 interacting genes: CDC42 GABARAPL2 MED10 MEOX2 PTGES3L-AARSD1 TAX1BP1 TEPSIN TFIP11 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 ZMYND19	25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		80263	7320
HPRD ID		15562	01533
Ensembl ID		ENSG00000134253	ENSG00000119048
Uniprot IDs		Q9H8W5	P63146
PDB IDs		2DS4	1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?
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