CCDC92 and TRIML2

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CCDC92	TRIML2
Description		coiled-coil domain containing 92	tripartite motif family like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process		Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Response To Retinoic Acid Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Coronary artery disease ( 29212778 28714974) Hand grip strength ( 29691431) HDL cholesterol ( 20686565) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 31453325) Hip circumference variance ( 31453325) Lymphocyte counts ( 32888494) Metabolite levels ( 23823483) Monocyte count ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 20686565) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference variance ( 31453325) Waist-to-hip ratio adjusted for BMI ( 26426971 30389748) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494 27863252)	Polycystic ovary syndrome ( 25574032)
Interacting Genes		12 interacting genes: CEP76 CHGB COG6 DISC1 FHL2 GOLGA2 PLEKHA5 PSMD8 TP53BP2 TRIM27 TRIML2 UBC	48 interacting genes: ABI2 BLOC1S2 CBY2 CCDC146 CCDC92 CCHCR1 CCNH CDR2 CTBP2 EIF2B1 EIF3M FAM90A1 FAM9C HGS ING5 ITGB3BP KRT15 KRT24 KRT27 KRT31 KRT34 KRT38 KRT75 MBD3L2 MBD3L3 MEOX1 MEOX2 NECAB2 NFKBID NUP62 PICK1 POLR1H POU6F2 SH2D4A STN1 SUMO2 SYCE2 TBC1D25 TCF4 TFIP11 TRIM54 TSEN54 TSG101 USHBP1 XAF1 ZBED1 ZBTB33 ZFHX3
Entrez ID		80212	205860
HPRD ID		16919	08696
Ensembl ID		ENSG00000119242	ENSG00000179046
Uniprot IDs		Q53HC0	B7ZLC3 Q8N7C3
PDB IDs
Enriched GO Terms of Interacting Partners?
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