PSCA and SLC7A1

Data Source:
BioGRID (two hybrid)

		PSCA	SLC7A1
Description		prostate stem cell antigen	solute carrier family 7 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Membrane Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex
	Molecular Function	Acetylcholine Receptor Binding	L-ornithine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity Arginine Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process	Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Neurotransmitter Receptor Activity	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane Arginine Transmembrane Transport Basic Amino Acid Transmembrane Transport
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Amino acid transport across the plasma membrane
Drugs			L-Lysine Arginine Ornithine
Diseases
GWAS		Bladder cancer ( 32117775 24163127 20972438 19648920) Blood urea nitrogen levels ( 31152163) Duodenal ulcer ( 22387998) Gastric adenocarcinoma (histologically verified) ( 26098866) Gastric atrophy ( 30753327) Gastric cancer ( 30189721 26098866) Non-cardia gastric cancer ( 26701879) Optic disc size ( 31809533) Pepsinogen I/II ratio ( 30753327) Severe gastric atrophy ( 30753327) Urinary tract infection frequency ( 28928442) Vertical cup-disc ratio ( 28073927)	Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		43 interacting genes: AGPAT5 AIG1 APOA2 APOL2 BCL2L2 BRICD5 CD53 CDIPT CMTM5 CTSA CYB561D2 DERL3 ERG28 INSIG2 JAGN1 LAT MOSPD3 PLP2 PLPP4 RUSF1 SLC16A4 SLC30A8 SLC35A1 SLC7A1 SMIM3 ST6GAL2 STX8 SYS1 TMEM140 TMEM147 TMEM218 TMEM239 TMEM243 TMEM262 TMEM42 TMEM54 TMEM86B TMEM97 TRARG1 TSPO2 UNC93A VAMP4 YIPF6	57 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 COMT CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4
Entrez ID		8000	6541
HPRD ID		03919	00091
Ensembl ID		ENSG00000167653	ENSG00000139514
Uniprot IDs		D3DWI6 O43653	A0A024RDQ9 P30825
PDB IDs
Enriched GO Terms of Interacting Partners?
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