SLC7A1 and GLB1

Data Source:
BioGRID (two hybrid)

		SLC7A1	GLB1
Description		solute carrier family 7 member 1	galactosidase beta 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Protein-containing Complex	Extracellular Region Cytoplasm Vacuole Golgi Apparatus Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	L-ornithine Transmembrane Transporter Activity L-histidine Transmembrane Transporter Activity Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity Arginine Transmembrane Transporter Activity L-lysine Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity	Beta-galactosidase Activity Protein Binding Galactoside Binding Protein Homodimerization Activity
	Biological Process	Amino Acid Transport L-amino Acid Transport Lysine Transport Ornithine Transport Positive Regulation Of T Cell Proliferation Amino Acid Import Across Plasma Membrane L-arginine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-ornithine Transmembrane Transport L-lysine Transmembrane Transport L-histidine Import Across Plasma Membrane Arginine Transmembrane Transport Basic Amino Acid Transmembrane Transport	Glycosaminoglycan Catabolic Process Glycosphingolipid Metabolic Process Galactose Catabolic Process Keratan Sulfate Catabolic Process Neutrophil Degranulation Cellular Carbohydrate Metabolic Process Response To Cortisone Response To Thyroglobulin Triiodothyronine
Pathways		Amino acid transport across the plasma membrane	Glycosphingolipid metabolism Keratan sulfate degradation HS-GAG degradation MPS IV - Morquio syndrome B Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation
Drugs		L-Lysine Arginine Ornithine	Lactose
Diseases			Galactosialidosis GM1 gangliosidosis Mucopolysaccharidosis type IV (MPS4), including: Morquio syndrome A (MPS4A); Morquio syndrome B (MPS4B)
GWAS		Blood osmolality (transformed sodium) ( 28360221) Diastolic blood pressure ( 27841878) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels ( 23823483) Systolic blood pressure ( 27841878 30578418)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Atopic dermatitis ( 23042114) Celiac disease ( 22057235) Eosinophil counts ( 29403010 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hepatocellular carcinoma ( 21105107) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		57 interacting genes: ADGRB3 APOA2 APP AQP6 ATP6V0C C8A CBLIF CCL4 CCL4L2 CD40 CD79A CDIPT CERS4 CMTM2 COMT CREB3L1 EMC6 FAM241B FATE1 FCER1G GALNT15 GET1 GLB1 GPR152 HERPUD2 LEPROT LEPROTL1 LMNA MFF MGST3 MS4A13 NUCB2 ORMDL3 PDCD1LG2 PNLIPRP1 PSCA PTPN9 RNF144A SACM1L SCN3B SEC23A SLC10A6 SLC18A2 SLC30A2 SLC39A2 SLC39A9 SLC52A1 SMCO4 ST6GAL2 STIM1 TMBIM6 TMEM14A TMEM19 TMEM237 TRARG1 TSPO2 YIPF4	11 interacting genes: CSNK2B CTSA DNAJB1 FOS GOLM1 NEU1 PLK1 SLC10A6 SLC30A2 SLC7A1 TK1
Entrez ID		6541	2720
HPRD ID		00091	01975
Ensembl ID		ENSG00000139514	ENSG00000170266
Uniprot IDs		A0A024RDQ9 P30825	B7Z6Q5 P16278
PDB IDs			3THC 3THD 3WEZ 3WF0 3WF1 3WF2 3WF3 3WF4
Enriched GO Terms of Interacting Partners?
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