ACTR5 and PPL

Data Source:
BioGRID (two hybrid)

		ACTR5	PPL
Description		actin related protein 5	periplakin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ino80 Complex	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Plasma Membrane Membrane Desmosome Extracellular Exosome
	Molecular Function	Protein Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Double-strand Break Repair DNA Recombination Regulation Of Transcription, DNA-templated Protein Deubiquitination ATP-dependent Chromatin Remodeling UV-damage Excision Repair	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		UCH proteinases DNA Damage Recognition in GG-NER	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Schizophrenia ( 25056061 29483656)	Adult body size ( 32376654) Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		2 interacting genes: CSNK2B PPL	43 interacting genes: ACTR5 AHCYL1 AKT1 ALAS1 C6orf141 CASP6 CEP57L1 COL17A1 DES EVPL HECTD3 IKZF1 ITSN1 KAZN KCTD21 KNSTRN KRT25 KRT39 KRT8 MRPL28 OPRM1 PBX4 PICK1 PLEKHA7 POF1B PPHLN1 PTEN RAB3IP SKIL TRAF2 TRIM27 TSC22D4 UBC UPRT USP7 VIM ZBTB26 ZNF165 ZNF213 ZNF263 ZNF474 ZSCAN1 ZSCAN16
Entrez ID		79913	5493
HPRD ID		08575	04187
Ensembl ID		ENSG00000101442	ENSG00000118898
Uniprot IDs		Q9H9F9	O60437
PDB IDs		6HTS	4Q28
Enriched GO Terms of Interacting Partners?
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