MCPH1 and PPA1

Data Source:
BioGRID (two hybrid)

		MCPH1	PPA1
Description		microcephalin 1	inorganic pyrophosphatase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Magnesium Ion Binding Inorganic Diphosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance	TRNA Aminoacylation For Protein Translation Phosphate-containing Compound Metabolic Process Diphosphate Metabolic Process
Pathways		Condensation of Prophase Chromosomes	Cytosolic tRNA aminoacylation Pyrophosphate hydrolysis
Drugs
Diseases		Primary microcephaly (MCPH)
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)	Blood protein levels ( 28240269)
Interacting Genes		68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2	10 interacting genes: ERBB2 HSPB1 MCPH1 MTRNR2L1 SETDB1 SUMO4 TP53 UBC UNC119 WIPI1
Entrez ID		79648	5464
HPRD ID		06174	01527
Ensembl ID		ENSG00000147316	ENSG00000180817
Uniprot IDs		Q8NEM0	Q15181 V9HWB5
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D	6C45 7BTN 7CMO
Enriched GO Terms of Interacting Partners?
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