PPA1 and SUMO4

Data Source:
HPRD (in vivo)

		PPA1	SUMO4
Description		inorganic pyrophosphatase 1	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus SUMO Ligase Complex
	Molecular Function	Magnesium Ion Binding Inorganic Diphosphatase Activity	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Phosphate-containing Compound Metabolic Process Diphosphate Metabolic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Cytosolic tRNA aminoacylation Pyrophosphate hydrolysis
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Dupuytren's disease ( 28886342)
Interacting Genes		10 interacting genes: ERBB2 HSPB1 MCPH1 MTRNR2L1 SETDB1 SUMO4 TP53 UBC UNC119 WIPI1	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		5464	387082
HPRD ID		01527	10584
Ensembl ID		ENSG00000180817	ENSG00000177688
Uniprot IDs		Q15181 V9HWB5	Q6EEV6
PDB IDs		6C45 7BTN 7CMO
Enriched GO Terms of Interacting Partners?
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