RNF128 and CD40LG

Data Source:
HPRD (in vivo)

		RNF128	CD40LG
Description		ring finger protein 128	CD40 ligand
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GO Annotations	Cellular Component	Cytoplasm Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Protein Localization To Lysosome Positive Regulation Of Protein Catabolic Process In The Vacuole	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Ub-specific processing proteases Ovarian tumor domain proteases	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Ruplizumab
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Alcoholic chronic pancreatitis ( 28754779) Creatinine levels ( 31015462) Estimated glomerular filtration rate ( 31015462)	CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		16 interacting genes: APPBP2 CD151 CD40LG CD81 CEP76 OTUB1 SNX17 TBK1 TP53 UBE2D1 UBE2E1 UBE2H UBE2I UBE2N UBE2T UBQLN2	6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		79589	959
HPRD ID		02340	02311
Ensembl ID		ENSG00000133135	ENSG00000102245
Uniprot IDs		Q8TEB7	P29965
PDB IDs		3ICU	1ALY 1I9R 3LKJ 3QD6 6BRB
Enriched GO Terms of Interacting Partners?
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