WDR25 and PRDM14

Data Source:
BioGRID (two hybrid)

		WDR25	PRDM14
Description		WD repeat domain 25	PR/SET domain 14
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Metal Ion Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Germ Cell Development Embryo Implantation Fertilization Regulation Of Gene Expression Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways			Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Menarche (age at onset) ( 27182965 25231870) Refractive error ( 32231278)	Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		31 interacting genes: AKAP8L C19orf54 CNFN CYSRT1 DVL3 FAM168B FHL3 FOXI1 GOLGA6L9 HSF2BP KRT31 KRT34 KRT40 KRTAP12-3 KRTAP15-1 KRTAP3-1 KRTAP6-3 LDOC1 LNX1 MKRN3 NBPF19 NOTCH2NLA NOTCH3 PFDN5 PNMA1 PRDM14 PSME3 TEPSIN TRIM23 UBXN11 ZNF34	67 interacting genes: ABI2 AKAP9 AQP1 ATPAF2 BAG4 BAHD1 BCAR3 BEX2 CARD10 CASP8 CBFA2T2 CDCA7L CHEK2 CREB5 DGCR6 DMRT3 EED EIF4E2 ENKD1 ERBB2 EZH2 FAM83A GAS8 GEM GLYCTK GPATCH2L HEXIM2 HOXB5 HOXC8 HSPB7 ID3 IDH1 KANK2 LNX1 MIA3 MRPL32 MYPOP PALB2 PATZ1 PAX2 PLEKHF2 PPP1R32 PRKAB2 PRPF31 PSMA1 PTPRJ RAD51D RBM10 RCOR3 RUNX1T1 RUSC1 SCNM1 SNRPC SUZ12 TCAF1 TEAD4 TEKT4 TLE5 TRIM41 TSGA10 TTC32 TXK USP2 WDR25 ZNF250 ZNF587 ZNF835
Entrez ID		79446	63978
HPRD ID		14649	11457
Ensembl ID		ENSG00000176473	ENSG00000147596
Uniprot IDs		A0A384NPW5 Q64LD2	Q9GZV8
PDB IDs
Enriched GO Terms of Interacting Partners?
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