CYBC1 and P2RX1

Data Source:
BioGRID (two hybrid)

		CYBC1	P2RX1
Description		cytochrome b-245 chaperone 1	purinergic receptor P2X 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Secretory Granule Membrane Protein-containing Complex Specific Granule Membrane Neuron Projection Membrane Raft Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Protein Binding	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Cation Channel Activity Protein Binding ATP Binding Drug Binding Zinc Ion Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Innate Immune Response Respiratory Burst After Phagocytosis	Serotonin Secretion By Platelet Regulation Of Vascular Associated Smooth Muscle Contraction Ion Transport Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Insemination Blood Coagulation Regulation Of Blood Pressure Neuronal Action Potential Platelet Activation Response To ATP Synaptic Transmission, Glutamatergic Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Ion Transport Neutrophil Degranulation Ceramide Biosynthetic Process Regulation Of Calcium Ion Transport Excitatory Postsynaptic Potential Cation Transmembrane Transport Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis
Pathways			Elevation of cytosolic Ca2+ levels Platelet homeostasis Neutrophil degranulation
Drugs			Promethazine
Diseases
GWAS			Mean platelet volume ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537)
Interacting Genes		64 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 BET1 C14orf180 C4orf3 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MFSD14B MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35C2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12	2 interacting genes: CYBC1 P2RX2
Entrez ID		79415	5023
HPRD ID		14630	07526
Ensembl ID		ENSG00000178927	ENSG00000108405
Uniprot IDs		A0A024R8W9 Q9BQA9	P51575
PDB IDs
Enriched GO Terms of Interacting Partners?
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