CYBC1 and CLN6

Data Source:
BioGRID (two hybrid)

		CYBC1	CLN6
Description		cytochrome b-245 chaperone 1	CLN6 transmembrane ER protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleolus Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Membrane Raft
	Molecular Function	Protein Binding	Protein Binding Lysophosphatidic Acid Binding Protein Homodimerization Activity Sulfatide Binding
	Biological Process	Innate Immune Response Respiratory Burst After Phagocytosis	Ganglioside Metabolic Process Lysosome Organization Lysosomal Lumen Acidification Visual Perception Cholesterol Metabolic Process Protein Catabolic Process Glycosaminoglycan Metabolic Process Locomotion Involved In Locomotory Behavior Cellular Macromolecule Catabolic Process Positive Regulation Of Proteolysis
Pathways
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS			Major depressive disorder ( 23377640) Restless legs syndrome ( 29029846)
Interacting Genes		64 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 BET1 C14orf180 C4orf3 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MFSD14B MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35C2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12	26 interacting genes: ARL13B CD79A CISD2 CLDN7 CLEC10A CPLX4 CREB3L1 CYBC1 EBAG9 EVI2B FAM209A FNDC9 GJA8 GORAB KIR2DL3 LIME1 LMNA LRRC25 RIC3 SLC22A23 SLC30A4 STX1A TEX264 TMEM139 TMEM237 TMPRSS2
Entrez ID		79415	54982
HPRD ID		14630	05991
Ensembl ID		ENSG00000178927	ENSG00000128973
Uniprot IDs		A0A024R8W9 Q9BQA9	A0A024R601 Q9NWW5
PDB IDs
Enriched GO Terms of Interacting Partners?
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