CENPO and FOSB

Data Source:
BioGRID (two hybrid)

		CENPO	FOSB
Description		centromere protein O	FosB proto-oncogene, AP-1 transcription factor subunit
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Kinetochore Nucleoplasm Cytosol Nuclear Body Mis6-Sim4 Complex	Chromatin Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	CENP-A Containing Nucleosome Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Drug Response To Morphine Positive Regulation Of Transcription By RNA Polymerase II Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 26426971 29273807) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cognitive function ( 28093568) Coronary artery disease ( 29212778) Height ( 28552196 25282103 23563607) Multiple sclerosis ( 24076602) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		7 interacting genes: CENPP CEP170P1 DCDC2 ERI3 FOS FOSB NECAB2	28 interacting genes: AGXT ATF2 CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUN JUNB JUND NCK2 NEDD9 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10
Entrez ID		79172	2354
HPRD ID		14414	01270
Ensembl ID		ENSG00000138092	ENSG00000125740
Uniprot IDs		Q9BU64	A0A024R0P6 K7EKC1 P53539
PDB IDs			5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM
Enriched GO Terms of Interacting Partners?
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